Taking this medicine with other drugs that make you sleepy or slow your breathing can cause dangerous or life-threatening side effects. Ask your doctor before taking Fioricet with a sleeping pill, opioid pain medicine, muscle relaxer, or medicine for anxiety, depression, or seizures.
Other drugs may interact with acetaminophen, butalbital, and caffeine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you use.
What may interact with this medication?
- Alcohol or medications that contain alcohol
- Antidepressants, especially MAOIs like isocarboxazid, phenelzine, tranylcypromine, and selegiline
- Antihistamines
- Benzodiazepines
- Carbamazepine
- Isoniazid
- Medications for pain like pentazocine, buprenorphine, butorphanol, nalbuphine, tramadol, and propoxyphene
- Muscle relaxants
- Naltrexone
- Phenobarbital, phenytoin, and fosphenytoin
- Phenothiazines like perphenazine, thioridazine, chlorpromazine, mesoridazine, fluphenazine, prochlorperazine, promazine, and trifluoperazine
- Voriconazole
This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.
Medications known to interact with Fioricet (Butalbital APAP Caffeine)
- abametapir topical
- abemaciclib
- abrocitinib
- acalabrutinib
- acebutolol
- acetylcarbromal
- acrivastine
- adagrasib
- adenosine
- aldesleukin
- alfentanil
- alfuzosin
- alosetron
- alpelisib
- alprazolam
- altretamine
- aminophylline
- amitriptyline
- amlodipine
- amobarbital
- amoxapine
- amprenavir
- anagrelide
- anisindione
- apalutamide
- apixaban
- apomorphine
- apraclonidine ophthalmic
- apremilast
- aprepitant
- aripiprazole
- armodafinil
- asenapine
- asparaginase erwinia chrysanthemi
- asparaginase escherichia coli
- aspirin
- atazanavir
- atogepant
- atorvastatin
- atropine
- avacopan
- avanafil
- avapritinib
- axitinib
- azatadine
- azilsartan medoxomil
- baclofen
- bedaquiline
- belladonna
- belumosudil
- bendamustine
- benztropine
- bepridil
- betamethasone
- bexarotene
- biperiden
- black cohosh
- boceprevir
- bortezomib
- bosutinib
- brentuximab
- brexanolone
- brexpiprazole
- brigatinib
- brimonidine ophthalmic
- brimonidine topical
- brivaracetam
- bromocriptine
- brompheniramine
- budesonide
- buprenorphine
- bupropion
- buspirone
- busulfan
- butabarbital
- butorphanol
- cabazitaxel
- cabozantinib
- calaspargase pegol
- calcifediol
- calcitriol
- canagliflozin
- cannabidiol
- cannabis
- capmatinib
- carbamazepine
- carbetapentane
- carbinoxamine
- cariprazine
- carisoprodol
- carvedilol
- caspofungin
- cenobamate
- ceritinib
- cetirizine
- cevimeline
- charcoal
- chlophedianol
- chloral hydrate
- chloramphenicol
- chlordiazepoxide
- chlorotrianisene
- chlorphenesin
- chlorpheniramine
- chlorpromazine
- chlorthalidone
- chlorzoxazone
- cholecalciferol
- cholestyramine
- cimetidine
- ciprofloxacin
- citalopram
- clemastine
- clevidipine
- clidinium
- clobazam
- clofarabine
- clomipramine
- clonazepam
- clonidine
- clorazepate
- clozapine
- cobimetinib
- cocaine nasal
- cocaine topical
- codeine
- conjugated estrogens
- copanlisib
- corticorelin
- corticotropin
- cortisone
- cosyntropin
- crizotinib
- cyclobenzaprine
- cycloserine
- cyclosporine
- cyproheptadine
- daclizumab
- dantrolene
- dapsone topical
- daridorexant
- darifenacin
- darolutamide
- darunavir
- dasatinib
- deferasirox
- delavirdine
- desipramine
- desvenlafaxine
- deutetrabenazine
- dexamethasone
- dexbrompheniramine
- dextromethorphan
- dezocine
- diazepam
- dicumarol
- dicyclomine
- difelikefalin
- diflunisal
- digitoxin
- dihydroergotamine
- dihydrotachysterol
- diltiazem
- dimenhydrinate
- diphenhydramine
- dipyridamole
- disopyramide
- disulfiram
- divalproex sodium
- docetaxel
- dolutegravir
- donepezil
- doravirine
- doxazosin
- doxepin
- doxepin topical
- doxercalciferol
- doxorubicin
- doxorubicin liposomal
- doxycycline
- doxylamine
- dronabinol
- dronedarone
- droperidol
- drospirenone
- duloxetine
- duvelisib
- echinacea
- efavirenz
- elacestrant
- elagolix
- eliglustat
- encorafenib
- enoxacin
- entacapone
- entrectinib
- enzalutamide
- epirubicin
- ergocalciferol
- ergonovine
- ergotamine
- erlotinib
- escitalopram
- esketamine
- eslicarbazepine
- estazolam
- esterified estrogens
- estradiol
- estradiol topical
- estrone
- estropipate
- eszopiclone
- ethanol
- ethinyl estradiol
- ethosuximide
- ethotoin
- etonogestrel
- etravirine
- everolimus
- exemestane
- ezogabine
- felbamate
- fenfluramine
- fenofibrate
- fenoldopam
- fenoprofen
- fentanyl
- fesoterodine
- fexinidazole
- finerenone
- flavoxate
- flibanserin
- fludrocortisone
- fluoxetine
- fluphenazine
- flurazepam
- fluvoxamine
- fosamprenavir
- fosaprepitant
- fosphenytoin
- fostamatinib
- fostemsavir
- furazolidone
- gabapentin
- gabapentin enacarbil
- ganaxolone
- gefitinib
- gilteritinib
- givosiran
- glasdegib
- glycerol phenylbutyrate
- glycopyrrolate
- grepafloxacin
- griseofulvin
- guanfacine
- halazepam
- haloperidol
- hemin
- heroin
- hydrocodone
- hydrocortisone
- hydromorphone
- hydroxyprogesterone
- hyoscyamine
- ibrutinib
- idelalisib
- ifosfamide
- iloperidone
- imatinib
- imipramine
- indinavir
- infigratinib
- interferon beta-1a
- interferon beta-1b
- irinotecan
- irinotecan liposomal
- isavuconazonium
- isocarboxazid
- isoniazid
- isradipine
- ivabradine
- ivacaftor
- ixabepilone
- ixazomib
- kava
- ketamine
- labetalol
- lamotrigine
- lapatinib
- larotrectinib
- lasmiditan
- lefamulin
- leflunomide
- lemborexant
- lenacapavir
- leniolisib
- lesinurad
- levamlodipine
- levetiracetam
- levobupivacaine
- levocetirizine
- levodopa
- levoketoconazole
- levomethadyl acetate
- levonorgestrel
- levorphanol
- levothyroxine
- levothyroxine / liothyronine
- lidocaine
- linagliptin
- linezolid
- liothyronine
- liotrix
- liraglutide
- lithium
- lofexidine
- lomitapide
- lonafarnib
- lorazepam
- lorlatinib
- losartan
- loxapine
- lumateperone
- lurasidone
- lurbinectedin
- macimorelin
- macitentan
- maprotiline
- maraviroc
- maribavir
- mavacamten
- medroxyprogesterone
- mefloquine
- megestrol
- melatonin
- mepenzolate
- meperidine
- mephenytoin
- mephobarbital
- mesoridazine
- metaxalone
- methadone
- methdilazine
- methocarbamol
- methohexital
- methotrexate
- methotrimeprazine
- methoxyflurane
- methscopolamine
- methsuximide
- methyldopa
- methylene blue
- methylergonovine
- methylprednisolone
- methysergide maleate
- metoclopramide
- metoprolol
- metronidazole
- metyrosine
- mibefradil
- midazolam
- midostaurin
- mifepristone
- mipomersen
- mirabegron
- mirtazapine
- mitotane
- mobocertinib
- modafinil
- molindone
- montelukast
- morphine
- morphine liposomal
- nabilone
- nalbuphine
- nalidixic acid
- naloxegol
- naltrexone
- nebivolol
- nefazodone
- nelfinavir
- nicardipine
- nicotine
- nifedipine
- nilotinib
- nimodipine
- nisoldipine
- nitisinone
- norethindrone
- norfloxacin
- norgestrel
- nortriptyline
- obeticholic acid
- olanzapine
- olaparib
- oliceridine
- olopatadine nasal
- olutasidenib
- omaveloxolone
- opicapone
- opium
- orphenadrine
- osilodrostat
- osimertinib
- ospemifene
- oxazepam
- oxcarbazepine
- oxtriphylline
- oxybutynin
- oxycodone
- oxymorphone
- ozanimod
- paclitaxel
- paclitaxel protein-bound
- pacritinib
- palbociclib
- paliperidone
- panobinostat
- paraldehyde
- paramethadione
- paricalcitol
- paroxetine
- pazopanib
- pegaspargase
- peginterferon beta-1a
- pemigatinib
- penbutolol
- pentazocine
- pentobarbital
- perampanel
- pergolide
- perphenazine
- pexidartinib
- phenacemide
- phenelzine
- phenobarbital
- phensuximide
- phenytoin
- pimavanserin
- pimozide
- pirtobrutinib
- pitolisant
- pneumococcal 13-valent vaccine
- pneumococcal 15-valent conjugate vaccine
- pneumococcal 20-valent conjugate vaccine
- pneumococcal 7-valent vaccine
- ponatinib
- pralsetinib
- pramipexole
- praziquantel
- prazosin
- prednisolone
- prednisone
- pregabalin
- primidone
- probenecid
- procarbazine
- prochlorperazine
- procyclidine
- progesterone
- progesterone topical
- promazine
- promethazine
- propafenone
- propantheline
- propiomazine
- propoxyphene
- propranolol
- protriptyline
- pyridoxine
- pyrilamine
- quazepam
- quetiapine
- quinestrol
- quinidine
- quinine
- ramelteon
- ranitidine
- ranitidine bismuth citrate
- ranolazine
- rasagiline
- regadenoson
- relugolix
- remdesivir
- remifentanil
- remimazolam
- repaglinide
- ribociclib
- rifampin
- rilpivirine
- riluzole
- riociguat
- ripretinib
- risperidone
- ritonavir
- rivaroxaban
- rolapitant
- ropeginterferon alfa-2b
- ropinirole
- ropivacaine
- rotigotine
- rucaparib
- rufinamide
- ruxolitinib
- safinamide
- saquinavir
- saxagliptin
- scopolamine
- secobarbital
- selegiline
- selpercatinib
- selumetinib
- sertraline
- sibutramine
- sildenafil
- silodosin
- sirolimus
- sirolimus protein-bound
- sodium oxybate
- sodium salicylate
- solifenacin
- sonidegib
- sorafenib
- sotorasib
- sparsentan
- st. john’s wort
- stiripentol
- sufentanil
- sulfinpyrazone
- sunitinib
- suvorexant
- tacrolimus
- tadalafil
- tafamidis
- tamoxifen
- tamsulosin
- tapentadol
- tasimelteon
- tazemetostat
- telaprevir
- telithromycin
- telmisartan
- temazepam
- temsirolimus
- tepotinib
- terazosin
- terbinafine
- teriflunomide
- tetrabenazine
- thalidomide
- theophylline
- thiabendazole
- thiethylperazine
- thioguanine
- thiopental
- thioridazine
- thiothixene
- thyroid desiccated
- tiagabine
- ticagrelor
- timolol
- tinidazole
- tipranavir
- tizanidine
- tofacitinib
- tolcapone
- tolterodine
- tolvaptan
- topiramate
- topotecan
- toremifene
- trabectedin
- tramadol
- tranylcypromine
- trazodone
- triamcinolone
- triazolam
- trifluoperazine
- triflupromazine
- trihexyphenidyl
- trimeprazine
- trimethadione
- trimethobenzamide
- trimipramine
- tripelennamine
- triprolidine
- trospium
- trovafloxacin
- tucatinib
- ubrogepant
- ulipristal
- valbenazine
- valerian
- valproic acid
- valsartan
- vemurafenib
- venetoclax
- venlafaxine
- verapamil
- vigabatrin
- vilazodone
- viloxazine
- voriconazole
- vortioxetine
- warfarin
- zaleplon
- zanubrutinib
- ziconotide
- zidovudine
- ziprasidone
- zolpidem
- zonisamide
Fioricet alcohol/food interactions
There are 6 alcohol/food interactions with Fioricet (acetaminophen / butalbital / caffeine).